Connecticut Maxillofacial Surgeons, llc
 

Once-Yearly Zoledronic Acid for Treatment of Postmenopausal Osteoporosis

December 17th, 2013 by ifi-admin

by Dennis M. Black, Ph.D., Pierre D. Delmas, M.D., Ph.D., Richard Eastell, M.D., Ian R. Reid, M.D., Steven Boonen, M.D., Ph.D., Jane A. Cauley, Dr.P.H., Felicia Cosman, M.D., Peter Lakatos, M.D., Ph.D., Ping Chung Leung, M.D., Zulema Man, M.D., Carlos Mautalen, M.D., Peter Mesenbrink, Ph.D., Huilin Hu, Ph.D., John Caminis, M.D., Karen Tong, B.S., Theresa Rosario-Jansen, Ph.D., Joel Krasnow, M.D., Trisha F. Hue, M.P.H., Deborah Sellmeyer, M.D., Erik Fink Eriksen, M.D., D.M.Sc., and Steven R. Cummings, M.D.,  for the HORIZON Pivotal Fracture Trial

Background
A single infusion of intravenous zoledronic acid decreases bone turnover and improves bone density at 12 months in postmenopausal women with osteoporosis. We assessed the effects of annual infusions of zoledronic acid on fracture risk during a 3-year period.

Methods
In this double-blind, placebo-controlled trial, 3889 patients (mean age, 73 years) were randomly assigned to receive a single 15-minute infusion of zoledronic acid (5 mg) and 3876 were assigned to receive placebo at baseline, at 12 months, and at 24 months; the patients were followed until 36 months. Primary end points were new vertebral fracture (in patients not taking concomitant osteoporosis medications) and hip fracture (in all patients). Secondary end points included bone mineral density, bone turnover markers, and safety outcomes.

Results
Treatment with zoledronic acid reduced the risk of morphometric vertebral fracture by 70% during a 3-year period, as compared with placebo (3.3% in the zoledronic-acid group vs. 10.9% in the placebo group; relative risk, 0.30; 95% confidence interval [CI], 0.24 to 0.38) and reduced the risk of hip fracture by 41% (1.4% in the zoledronic-acid group vs. 2.5% in the placebo group; hazard ratio, 0.59; 95% CI, 0.42 to 0.83). Nonvertebral fractures, clinical fractures, and clinical vertebral fractures were reduced by 25%, 33%, and 77%, respectively (P<0.001 for all comparisons). Zoledronic acid was also associated with a significant improvement in bone mineral density and bone metabolism markers. Adverse events, including change in renal function, were similar in the two study groups. However, serious atrial fibrillation occurred more frequently in the zoledronic acid group (in 50 vs. 20 patients, P<0.001).

Conclusions
A once-yearly infusion of zoledronic acid during a 3-year period significantly reduced the risk of vertebral, hip, and other fractures. (ClinicalTrials.gov number, CT00049829.)

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“Three-Dimensional Ridge Augmentation with Xenograft and Recombinant Human Platelet-Derived Growth Factor-BB in Humans: Report of Two Cases”

December 17th, 2013 by ifi-admin

by Massimo Simion, MD, DDS, Isabella Rocchietta, DDS, & Claudia Dellavia, DDS

A paper presenting two patients who underwent three-dimensional ridge augmentation using a xenograft in combination with recombinant human platelet-derived growth factor-BB (rhPDGF-BB).  The report suggests that the use of rhPDGF-BB in combination with a deproteinized bovine graft may have the potential to regenerated large three-dimensional alveolar defects in humans.

The article renders very nice photo and radiographich images of the post-treatment ridge forms and demonstrates, at least on two patients with limited follow-up, that vertical ridge augmentation in the mandibular arch may be possible under these special conditions.

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“Surgical and Orthodontic Management of Impacted Maxillary Canines”

December 17th, 2013 by ifi-admin

by Vincent G. Kokich, DDS, MSD

This landmark article covers a contemporary approach to the exposure and management of the impacted maxillary canine.  The concept of allowing for self eruption after exposure of the palatally impacted is discussed along with the surgical recommendations for this approach.  Various positions of canine impaction are covered, classified and reviewed as to how one might best approach their recovery.

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All-on 4: “An Alternative Surgical Technique for Full Arch Reconstruction”

December 17th, 2013 by ifi-admin

by Nobel BioCare

This brochure is about everything “all-on-4″.  With a decade of experience the all-on-4 surgical technique and restorative option presents a less expensive and secure option for those looking for a complete maxillary or mandibular implant supported reconstruction.  CTMAX’s experience supports these statistics and further verifies that the surgical side of this treatment can be rendered with a brief recovery and an accelerated timeline to the finished restoration.  Immediate loading is possible in many cases.

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“Three-Dimensional Ridge Augmentation with Xenograft and Recombinant Human Platelet-Derived Growth Factor-BB in Humans: Report of Two Cases”

December 17th, 2013 by ifi-admin

by Massimo Simion, MD, DDS, Isabella Rocchietta, DDS, & Claudia Dellavia, DDS

A paper presenting two patients who underwent three-dimensional ridge augmentation using a xenograft in combination with recombinant human platelet-derived growth factor-BB (rhPDGF-BB).  The report suggests that the use of rhPDGF-BB in combination with a deproteinized bovine graft may have the potential to regenerated large three-dimensional alveolar defects in humans.

The article renders very nice photo and radiographich images of the post-treatment ridge forms and demonstrates, at least on two patients with limited follow-up, that vertical ridge augmentation in the mandibular arch may be possible under these special conditions.

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“The Profile Prosthesis: An Aesthetic Fixed Implant-Supported Restoration for the Resorbed Maxilla”

December 17th, 2013 by ifi-admin

by Paul A. Schnitman, DDS, MSD

This article discusses a method for the predictable fabrication of fixed detachable maxillary reconstructions that abut and precisely follow the gingival contours — regardless of implant angulation or position. The technique reorders the traditional implant protocol and delays abutment selection until the definitive tooth position has been established. In this manner, final abutment selection and framework design become a single, integrated process
that results in improved aesthetics, reduced angulation difficulties, and elimination of the phonetic concerns traditionally associated with fixed maxillary prostheses.

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“The Maxillary Sinus: Challenges and Treatments for Implant Placement”

December 17th, 2013 by ifi-admin

by Georgios Tasoulis, D.M.D., Suellan Go Yao, D.M.D. and James Burke Fine, D.M.D.

This article is a fresh review of subantral grafting published in the February 2011 Compendium.  The article summarizes nicely the various sinus lift techniques, the clinical situations in which to apply these techniques and the complications associated with them.  A comparison of graft materials is briefly discussed as well as implant size as it relates to the success of various antral grafting techniques.

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“NobelReplace, Snappy Abutment, and NobelProcera Crown Zirconia in the Posterior”

December 17th, 2013 by ifi-admin

by Peter K. Moy, DMD and Baldwin W. Marchack, DDS, MBA, FAGD, FICD, FACD

A 60-year-old man presented with a 10-mm pocket on the distal aspect of his left mandibular molar. A nonsmoker, he had no positive medical history relevant to his dental treatment. Clinical examination along with radiographic evaluation confirmed that the root canal filling had failed, and the tooth had fractured. The patient elected for implant treatment, to be delivered in a staged approach, with immediate temporization.

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“Immediate Implant Placement, Provisionalization, and Restoration for Single Tooth Replacement”

December 17th, 2013 by ifi-admin

by Michael Sesemann DDS and Bruce Kuhn, MD, DDS

A 27-year-old woman presented to the office with a chief complaint concerning the esthetics of the porcelain-fused-to-metal (PFM) crowns on her maxillary lateral incisors, which had been placed at different times in the early 1990s. The objective was to use contemporary materials and techniques to have them blend better with her natural dentition. In general, the patient’s periodontal health was excellent. A slight amount of inflammation of the gingival tissues was present around the PFM crowns.

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“Immediate Implant Placement and Provisionalization of a Single Anterior Tooth”

December 17th, 2013 by ifi-admin

by Robert M. Bentz, DMD, FACP

The patient was a 47-year-old building contractor with crowns on both his central maxillary incisors. He experienced a traumatic injury that fractured the left crown at the gum line. As he had no other facial lacerations, he presented for dental treatment immediately after the accident. His medical and dental histories were otherwise unremarkable. The patient chose to have the tooth extracted, followed by immediate implant placement and temporization.

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